Thanks to a formal collaboration agreement, the section in Bologna is hosted within the Orthopedic Rizzoli Institute. In spite of this complex history, the various components of the Institute share common scientific interests with a high level of methodological complementarity. IGM combines investigations on basic cellular processes, renowned at international level, with applied and translational research. IGM is mainly involved in basic research on fundamental biological processes. Four main lines of investigation can be identified, on which converge the activities of groups in Pavia e Bologna: IGM researches on basic biological mechanisms is completed with a likewise qualified translational research. Three main research fields can be identified: Research activities of the various groups are strictly interrelated utilizing the front-line methods of the modern biology biochemical and pharmacological approach, molecular genetics and biology, cellular biology and bio-computing. National Research Council of Italy. Abnormal Metabolic states, cellular stressors and NeuroDegenerative processes. Basic methodologies for innovation in the diagnosis and treatment of multifactorial diseases.

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Their clinical presentation is often heterogeneous, with frequent involvement of the respiratory tract, the kidney, the skin and the joints. Implications for Diagnosis, Clinical Manifestations, and Management. Background Granulomatosis with polyangiitis GPA and microscopic polyangiitis MPA are multi-systemic diseases associated with anti-neutrophil cytoplasmic antibody ANCA often characterized by overlapping clinical manifestations. CDS provides high positive predictive value for diagnosing GCA and allows for a significant reduction in temporal artery biopsies. The aim of this review is to provide a comparative summary of the main advantages and pitfalls of RCTs and real-world data, emphasizing the need for a constant integration of all available levels of evidence to provide the best care for patients. A Real Life Experience. Moreover, it suggests that renin-angiontensin system antagonists decrease osteopontin levels-this effect is consistent with the inhibitory effect of these drugs on osteopontin renal expression, detected in animal models by other authors, and may provide a new rationale for their employment. The role of ultrasound in the diagnosis and follow-up of large-vessel vasculitis: Methods Clinical records of AAV patients from three third level rheumatologic centers in Northern Italy were retrospectively analyzed. Il dottore ha la cura parte due

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